VThunter

Cat

Scientific Name: Felis catus

Taxonomy: Cellular organisms-> Eukaryota-> Opisthokonta-> Metazoa-> Eumetazoa-> Bilateria-> Deuterostomia-> Chordata-> Craniata-> Vertebrata-> Gnathostomata-> Teleostomi-> Euteleostomi-> Sarcopterygii-> Dipnotetrapodomorpha-> Tetrapoda-> Amniota-> Mammalia-> Theria-> Eutheria-> Boreoeutheria-> Laurasiatheria-> Carnivora-> Feliformia-> Felidae

Human coronavirus NL63

Family: Coronaviridae

Receptor: ACE2

Receptor ACE2 information

Summary: The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. ACE2 is known to be expressed in various human organs, and its organ- and cell-specific expression suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronavirus HCoV-NL63 and the human severe acute respiratory syndrome coronaviruses, SARS-CoV and SARS-CoV-2, the latter is the causative agent of coronavirus disease-2019 (COVID-19). Multiple splice variants have been found for this gene and the dACE2 (or MIRb-ACE2) splice variant has been found to be interferon inducible. [provided by RefSeq, Nov 2020] [NCBI] [Proteinatlas]

Data Source

Data set information

Project	Date	Technology	Tissue	Condition	Cell	PMID/DOI
Vthunter_0028	2021.04	10X Genomics	Esophagus	Normal	1928	Link
Vthunter_0029	2021.04	10X Genomics	Eyelid	Normal	679	Link
Vthunter_0030	2021.04	10X Genomics	Heart	Normal	8209	Link
Vthunter_0031	2021.04	10X Genomics	Kidney	Normal	2831	Link
Vthunter_0032	2021.04	10X Genomics	Liver	Normal	7889	Link
Vthunter_0033	2021.04	10X Genomics	Lung	Normal	8591	Link
Vthunter_0034	2021.04	10X Genomics	Rectum	Normal	1503	Link